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・ Hook Me Up (song)
・ Hook Mountain State Park
・ Hook n Sling
・ Hook nail
・ Hook Norton
・ Hook Norton Brewery
・ Hook Norton F.C.
・ Hook Norton Ironstone Partnership
・ Hook Norton ironstone quarries
・ Hook Norton ironstone quarries (Baker)
・ Hook Norton ironstone quarries (Brymbo)
・ Hook Norton railway station
・ Hook of Holland
・ Hook Peninsula
・ Hook Point
Hook protein
・ Hook railway station
・ Hook River
・ Hook shot
・ Hook Street
・ Hook sword
・ Hook turn
・ Hook Up
・ Hook Windmill
・ Hook Wood
・ Hook Ya Crook
・ Hook's Drug Stores
・ Hook's Tavern
・ Hook, East Riding of Yorkshire
・ Hook, Fareham


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Hook protein : ウィキペディア英語版
Hook protein

HOOK is a family of evolutionarily related proteins.
This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved N-terminal domain mediates attachment to microtubules, whereas the central coiled coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.
== Examples ==
Proteins containing this domain include:
* HOOK1; HOOK2; HOOK3

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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